Evidence map›Paper›PMID 42222578›Full record

ArticleChemical & biomedical imaging2026

Unraveling the Reverse Hofmeister Effect of 3,3',5,5'-Tetramethylbenzidine for Anion-Responsive Color-Changing Hydrogels.

Yuan Xu, Hong Yang, Kangchun Fu, Yu Liu, Yanfei Shen, Songqin Liu, Yuanyuan He, Yuanjian Zhang

Abstract read
In one paragraph

Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuan XuJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.
Hong YangJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.
Kangchun FuJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.
Yu LiuJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.
Yanfei ShenJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.ORCID https://orcid.org/0000-0003-0369-5920
Songqin LiuJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.ORCID https://orcid.org/0000-0002-4686-5291
Yuanyuan HeCollege of Material and Textile Engineering, Jiaxing University, Jiaxing 314001 Zhejiang, China.
Yuanjian ZhangJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, School of Chemistry and Chemical Engineering, Medical School, Southeast University, Nanjing 211189, China.ORCID https://orcid.org/0000-0003-2932-4159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ions are essential regulators of biomolecular stability and function, and their effects are classically summarized in the Hofmeister series. While extensive studies have focused on proteins and other biomacromolecules, whether small molecules exhibit similar ion-specific behaviors remains largely unexplored. Herein, we report the common blue oxidation product of 3,3',5,5'-tetramethylbenzidine (TMB

Indexed as

colorimetric sensingHofmeister effectnanozymespecific ion effectTMB

Identifiers

PMID42222578
PMCPMC13217324

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.