ArticleChemical & biomedical imaging2026
FLIM Characterization of Staurosporine-Induced Changes in Endogenous Cellular Autofluorescence.
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Autofluorescence arising from endogenous fluorophores like Flavins and NADH offers a label-free approach to monitoring cellular metabolism. In this study, we investigated the changes in intrinsic fluorescence under chemically induced mitochondrial stress in live cells. Using confocal imaging, Raman spectroscopy, fluorescence lifetime imaging, and high-performance liquid chromatography, we characterize a reproducible increase in green autofluorescence. Lifetime signatures suggest involvement of flavin adenine dinucleotide (FAD), a key mitochondrial factor. This enhanced autofluorescence response appears both intracellularly and extracellularly and is consistent across three cancer cell lines and HEK293 cells. Our findings highlight autofluorescence as a sensitive, label-free reporter of cellular metabolic state, with potential applications in real-time monitoring of cell stress and death.
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