ArticleChemical & biomedical imaging2026
Development of an
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strain-promoted azide-alkyne cycloaddition (SPAAC) reactions between azides and strained alkynes are some of the most widely used bioorthogonal reactions for molecular imaging applications, such as in positron emission tomography (PET). Radiolabeled azides and alkynes have been developed for click reactions; however, very few compounds have been studied in the intracellular space, where stability, selectivity, and reactivity may be affected by the surrounding complex intracellular environment. Motivated by the lack of tools to evaluate azide tracer candidates for bioorthogonal click reactions in the intracellular compartment, we designed and synthesized Hoechst-DBCO, a Hoechst 33258 derivative that accumulates in cells. Hoechst 33258 has strong DNA binding properties and is used as a courier to deliver dibenzocyclooctyne (DBCO), a strained alkyne, into the nucleus to track click reactions in living cells. The ultimate aim of this study was to develop an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.