ArticleBiochemistry and biophysics reports2026
Exendin-4 protects brain endothelial cell damage against hyperammonemic condition.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with elevated ammonia levels, which impair blood-brain barrier (BBB) integrity and trigger chronic neuroinflammation. This study aims to evaluate the therapeutic potential of exendin-4, a glucagon-like peptide-1 receptor agonist, in mitigating BBB disruption and inflammation induced by hyperammonemia. We conducted experiments using a HE mouse model and
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