Evidence map›Paper›PMID 42222483›Full record

SynthesisPeerJ2026

Prognostic value of lymphocyte to monocyte ratio for cervical cancer: a systematic review and meta-analysis.

Guanjun Zhao, Masmuha Marshed Al Ramadhan, Yifang Zhang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guanjun Zhao *Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong Province, China.
Masmuha Marshed Al Ramadhan *Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong Province, China.
Yifang ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Systemic inflammatory biomarkers have been associated with outcomes across multiple malignancies, including cervical cancer. The prognostic value of the pretreatment lymphocyte-to-monocyte ratio (LMR) in cervical cancer remains inconsistent across published studies. We therefore performed a systematic review and meta-analysis to clarify the association between pretreatment LMR and survival outcomes in cervical cancer. Methods: PubMed, Web of Science, Embase, and the Cochrane Library were searched from database inception to November 14, 2025. Studies evaluating pretreatment LMR in relation to survival outcomes in cervical cancer were included. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled for overall survival (OS) and progression-free survival (PFS). Subgroup, sensitivity, meta-regression, and publication-bias analyses were also performed. Results: Eighteen studies comprising 22 independent cohorts ( Conclusions: Current evidence suggests that a low pretreatment LMR is significantly associated with poorer OS and PFS in cervical cancer. Pretreatment LMR may therefore represent an accessible and cost-effective biomarker for pretreatment risk stratification. Nevertheless, prospective studies are warranted to validate clinically meaningful cut-off values, standardize analytical approaches, and further define the clinical utility of LMR in cervical cancer.

Indexed as

LymphocytesMonocytesUterine Cervical NeoplasmsFemaleHumansLymphocyte CountPrognosisCervical cancerLymphocyte-to-monocyte ratioMeta-analysisPrognosisSystematic review

Identifiers

PMID42222483
PMCPMC13221991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.