ArticleCancer informatics2026
Integrated Ferroptosis and Immune Features Are Associated With Overall Survival in Bladder Urothelial Carcinoma: A TCGA-Based Analysis.
Article in Cancer informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: To investigate the prognostic value of ferroptosis-related and immune-related transcriptional features in bladder urothelial carcinoma (BUC) and to evaluate whether their integration provides incremental prognostic information beyond conventional clinical factors. Methods: Transcriptomic and clinical data of patients with BUC were obtained from The Cancer Genome Atlas (TCGA) as the training cohort. Ferroptosis and immune scores were constructed based on predefined gene sets using a Results: Neither ferroptosis nor immune scores alone were significantly associated with overall survival in Kaplan-Meier analyses. Multivariable Cox regression showed a directionally protective effect of immune score and a non-significant risk trend for ferroptosis score. Integration of ferroptosis and immune features resulted in modest improvement in prognostic performance compared with clinical models alone. These findings were consistent across external validation cohorts. Restricted cubic spline analysis revealed a nonlinear association for immune score but not for ferroptosis score. Sensitivity analyses incorporating tumor grade yielded similar results, supporting robustness of the findings. Conclusion: Ferroptosis and immune transcriptional features provide limited but consistent incremental prognostic information in bladder urothelial carcinoma. These findings are exploratory and hypothesis-generating, suggesting that integration of ferroptosis and immune biology may offer complementary insights but is not yet sufficient for clinical application.
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