ReviewFrontiers in oncology2026
Modeling gliomas with organoids: reconstructing the human neural microenvironment for translational neuro-oncology.
Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Gliomas represent some of the most lethal and biologically complex tumors of the central nervous system, with poor outcomes across both adult and pediatric populations. Beyond tumor-intrinsic genetic alterations, glioma progression is increasingly recognized to be driven by dynamic interactions with the neural microenvironment, particularly through direct tumor-neuron communication. Studies of adult and pediatric gliomas, including glioblastoma (GBM) and diffuse midline glioma (DMG), using single-cell profiling and multi-omics technologies have revealed extensive tumor intrinsic and extrinsic heterogeneity, with phenotypically and genetically plastic tumor cells actively engaged with neurons, glia, vasculature, and immune compartments that collectively reshape the neural microenvironment to promote tumor growth, invasion, and therapy resistance. Conventional two-dimensional
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