Evidence map›Paper›PMID 42222364›Full record

ArticleFrontiers in neuroscience2026

Serum hypocretin, neurofilament heavy chain, and interleukin-1β as combined predictors of sleep disorders following acute ischemic stroke.

Chaowei Wang, Yunqing Mao, Shuo Wang, Li Liu, Guang Yao

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Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chaowei WangDepartment of Neurology, The First Affiliated Hospital of Henan Medical University, Henan Provincial Key Laboratory of Neural Repair and Protein Modification, Henan Provincial International Joint Laboratory of Neural Repair for Senile Dementia, Henan Provincial Engineering Research Center of Neural Repair, Henan Provincial Engineering Technology Research Center of Neural Repair, and Henan Provincial Medical Key Laboratory of Neurology, Weihui, Henan, China.
Yunqing MaoDepartment of Neuroelectrophysiology, The First Affiliated Hospital of Henan Medical University, Henan Provincial Key Laboratory of Neural Repair and Protein Modification, Henan Provincial International Joint Laboratory of Neural Repair for Senile Dementia, Henan Provincial Engineering Research Center of Neural Repair, Henan Provincial Engineering Technology Research Center of Neural Repair, and Henan Provincial Medical Key Laboratory of Neurology, Weihui, Henan, China.
Shuo WangDepartment of Neurology, The First Affiliated Hospital of Henan Medical University, Henan Provincial Key Laboratory of Neural Repair and Protein Modification, Henan Provincial International Joint Laboratory of Neural Repair for Senile Dementia, Henan Provincial Engineering Research Center of Neural Repair, Henan Provincial Engineering Technology Research Center of Neural Repair, and Henan Provincial Medical Key Laboratory of Neurology, Weihui, Henan, China.
Li LiuDepartment of Neurology, The First Affiliated Hospital of Henan Medical University, Henan Provincial Key Laboratory of Neural Repair and Protein Modification, Henan Provincial International Joint Laboratory of Neural Repair for Senile Dementia, Henan Provincial Engineering Research Center of Neural Repair, Henan Provincial Engineering Technology Research Center of Neural Repair, and Henan Provincial Medical Key Laboratory of Neurology, Weihui, Henan, China.
Guang YaoSchool of Mathematics and Statistics, Xinxiang University, Xinxiang, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sleep disorders represent a common and impactful complication following acute ischemic stroke (AIS). This study aimed to identify clinical risk factors and evaluate the predictive value of serum hypocretin (Hcrt), neurofilament heavy chain (NfH), and interleukin-1 beta (IL-1β) for post-stroke sleep disorders. Methods: We conducted a retrospective observational study of 256 patients with AIS. Patients were classified into sleep disorder ( Results: Sleep disorders were present in 62.9% of patients. Nine independent risk factors were identified: age ≥ 65 years (OR = 2.059), snoring history (OR = 1.980), prior stroke (OR = 2.036), lower ADL scores (OR = 1.839), higher HAMD (OR = 1.726) and NIHSS scores (OR = 1.677), decreased serum Hcrt (OR = 1.863), elevated NfH (OR = 2.020), and elevated IL-1β (OR = 1.793; all Conclusion: Clinical variables alongside altered levels of Hcrt, NfH, and IL-1β serve as independent predictors of post-stroke sleep disorders. The combined three-biomarker panel, reflecting neuroendocrine dysregulation, axonal injury, and systemic inflammation, demonstrates substantially superior predictive accuracy over individual biomarkers and offers a clinically practical tool for early identification of high-risk patients.

Indexed as

acute ischemic strokehypocretininterleukin-1βneurofilament heavy chainsleep disorders

Identifiers

PMID42222364
PMCPMC13220776

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.