ArticleFrontiers in cell and developmental biology2026
Association of baPWV and CD34
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vascular aging plays a key role in the pathogenesis of Alzheimer's disease (AD). This study evaluated the diagnostic value of arterial stiffness and endothelial progenitor CD34 Methods: We measured brachial-ankle pulse wave velocity (baPWV) and conducted CGA in subjects with AD (n = 58), mild cognitive impairment (MCI, n = 31), and non-cognitive impairment (NCI, n = 36). Plasma levels of SIRT1-derived circRNAs (including hsa_circ_0093884) within EPC-Exos were quantified. Logistic regression and ROC curve analyses were used to assess diagnostic performance, with internal validation performed using bootstrapping (1,000 resamplings) to evaluate model stability. Aβ1-42-treated SH-SY5Y cells were used as a neuronal model to validate the downstream neuroprotective effects of circRNA. The miR-375/SIX4 regulatory axis was investigated using bioinformatics prediction, biotin-RNA pull-down, dual-luciferase reporter assays, and co-transfection experiments. Results: Compared to MCI and NCI groups, AD patients exhibited significantly higher baPWV and lower levels of EPC-Exosomal hsa_circ_0093884 ( Conclusion: EPC-Exosomal hsa_circ_0093884 and baPWV are valuable diagnostic biomarkers associated with Alzheimer's disease. The hsa_circ_0093884/miR-375/SIX4 axis offers a novel therapeutic target, supporting a potential vascular-neuronal axis connecting vascular aging to neurodegeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.