Evidence map›Paper›PMID 42222328›Full record

ArticleJournal of traditional and complementary medicine2026

Cinnamaldehyde inhibits the NLRP3 inflammasome and inflammatory response by reducing oxidative stress in Neisseria gonorrhoeae-infected macrophages.

Kuo-Feng Hua, Hsiao-Wen Chiu, Miao-Mei Chen, Wei-Ting Wong, Wen-Chiuan Tsai, Wen-Yu Lin, Chun-Hsien Wu, Chien-Chun Wang, Chung-Hua Hsu, Oleg V Chernikov and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kuo-Feng HuaDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Hsiao-Wen ChiuDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Miao-Mei ChenDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wei-Ting WongDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Wen-Chiuan TsaiDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wen-Yu LinDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chun-Hsien WuDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chien-Chun WangInfectious Disease Division, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan.
Chung-Hua HsuLinsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan.
Oleg V ChernikovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
Yerra Koteswara RaoDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Hsien-Ta HsuDivision of Neurosurgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Chen-Lung HoDivision of Wood Cellulose, Taiwan Forestry Research Institute, Taipei, Taiwan.
Lan-Hui LiDepartment of Laboratory Medicine, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Gonorrhoea, a common sexually transmitted disease, is caused by Experimental procedure: Protein expression was assessed by ELISA and Western blotting. Intracellular H Results and conclusion: CA inhibited caspase-1 activation and reduced IL-1β, IL-18, and NLRP3 secretion, indicating suppression of NLRP3 inflammasome activity. It also decreased

Indexed as

Antibacterial agentCinnamaldehydeMacrophagesNeisseria gonorrhoeaeNLRP3 inflammasomeReactive oxygen species

Identifiers

PMID42222328
PMCPMC13221309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.