ArticleGastro hep advances2026
Up to 1 in 4 Veterans With Primary Biliary Cholangitis May Have Cirrhosis by the Time of Its Diagnosis.
Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Existing studies suggest that up to half of individuals with primary biliary cholangitis (PBC) remain undiagnosed, contributing to lack of clarity on true prevalence of PBC. We aim to evaluate the prevalence of PBC among a national cohort of US veterans. Methods: National Veterans Affairs data from January 1, 2010, to April 30, 2025, were evaluated to identify adults with PBC using a combination of International Classification of Diseases (ICD)-9/10 diagnostic codes (57.16, K74.3) and/or presence of positive antimitochondrial antibody. Prevalence of PBC (per 100,000 persons) and proportion of patients with cirrhosis at time of PBC diagnosis was evaluated by age, sex, and race/ethnicity. Results: Among over 5.13 million veterans who had ≥1 annual health-care encounter, the prevalence of PBC ranged from 19.5 to 76.2 per 100,000 persons when using different combinations of ICD-9/10 codes and antimitochondrial antibody diagnostic criteria. Among most scenarios, PBC prevalence was highest among women, older individuals (age ≥60 years), and Hispanic, or Asian/Pacific Islanders. The proportion of patients with cirrhosis at time of PBC diagnosis ranged from 10.7% to 26.4%, with generally higher rates of cirrhosis in men vs women. Conclusion: Among a national cohort US veterans, the prevalence of PBC ranged from 19.5 to 76.2 per 100,000 persons when evaluating various diagnostic criteria. It is concerning that up to a quarter of patients may have already had cirrhosis at time of PBC diagnosis, emphasizing the importance of greater awareness of timely diagnosis and treatment of PBC.
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