Evidence map›Paper›PMID 42222278›Full record

ArticleTransboundary and emerging diseases2026

Evaluating Potential Deployment Strategies for Oral Delivery of Vaccines for Cervids.

Amanda S Zimmerling, Scott Napper

Abstract read
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amanda S ZimmerlingOne Health Medical Technologies, Saskatoon, Saskatchewan, Canada.ORCID https://orcid.org/0000-0002-8758-6133
Scott NapperVaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada, usask.ca.ORCID https://orcid.org/0000-0003-1948-4538

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While vaccination is the most efficacious strategy for landscape-scale disease management, its success is predicated on overcoming concurrent hurdles in both laboratory-scale vaccine development and the logistical and behavioral complexities of field delivery to targeted wildlife populations, such as cervids. As laboratory effectiveness and successful field deployment of vaccines are interdependent, these efforts should be performed concurrently, with findings in one influencing progress in the other. A proactive approach for development of effective deployment strategies also minimizes any logistical bottlenecks that could occur following vaccine regulatory approval. This multiregional field study utilized a rotational crossover design across 19 sites in Alberta and Saskatchewan (May-August 2025) to quantify the behavioral efficacy of two candidate vaccine delivery matrices (thin film and liquid-filled packets [boba]) in combination with a variety of common cervid attractants. Remote camera monitoring was employed to assess target cervid (deer, elk, and moose) foraging preference, nontarget species uptake, and individual repeat visitation frequency. The thin-film matrix, presented within peas as food attractant, was found to be the optimal bait-delivery matrix maximizing target uptake. This analysis simultaneously quantified two critical operational hurdles (1) high nontarget consumption and (2) repeat consumption, or large-dose consumption, by individual cervids. These behavioral constraints invalidate a generic scatter-bait approach and underscore a challenge in delivery engineering. These findings provide the quantitative parameters required to support the development of a "smart" oral delivery system that incorporates remote species recognition and portion control to achieve cost-effective, single-dose delivery in wild populations.

Indexed as

DeerVaccinationVaccinesAdministration, OralAlbertaAnimalsAnimals, WildSaskatchewanVaccinesbait preferencecervidchronic wasting diseasenontarget speciesoral delivery systemtrail cameravaccine

Identifiers

PMID42222278
PMCPMC13216712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.