Evidence map›Paper›PMID 42222270›Full record

ArticleNeuroimage. Reports2026

A parameterized gamma-variate function can describe the temporal response of cerebral blood flow after Acetazolamide injection in Moyamoya patients.

Joao M Sousa, Teodor Svedung Wettervik, Fartein Velle, Alex A Bhogal, Johan Berglund, Per Enblad, Johan Wikström, Anders Lewén, Markus Fahlström

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Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Joao M SousaDepartment of Medical Physics, Uppsala University Hospital, Uppsala, Sweden.
Teodor Svedung WettervikDepartment of Medical Sciences, Neurosurgery, Uppsala University, Uppsala, Sweden.
Fartein VelleDepartment of Medical Sciences, Neurosurgery, Uppsala University, Uppsala, Sweden.
Alex A BhogalTranslational Neuroimaging Group, Center for Imaging Science, University Medical Center Utrecht, Utrecht University, the Netherlands.
Johan BerglundDepartment of Medical Physics, Uppsala University Hospital, Uppsala, Sweden.
Per EnbladDepartment of Medical Sciences, Neurosurgery, Uppsala University, Uppsala, Sweden.
Johan WikströmDepartment of Surgical Sciences, Neuroradiology, Uppsala University, Uppsala, Sweden.
Anders LewénDepartment of Medical Sciences, Neurosurgery, Uppsala University, Uppsala, Sweden.
Markus FahlströmDepartment of Medical Physics, Uppsala University Hospital, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Quantitative modelling of the temporal response of cerebral blood flow (CBF) following Acetazolamide (ACZ) may be performed using a parameterized gamma-variate function with physiologically interpretable parameters. When combined with sequential CBF measurement before and after administration of ACZ, such a model could enable assessment of cerebrovascular reserve (CVR) while accounting for regional differences in the timing of the vascular response between steno-occlusive and unaffected territories. To evaluate this approach, we applied the model to patients with moyamoya disease (MMD). Methods: Twenty-four MMD patients underwent MRI including structural- and sequential multi-delay arterial spin labeling acquisitions before and after ACZ injection. Non-linear least squares curve fitting was performed on CBF values extracted from vascular regions. Root mean squared error (RMSE), absolute and relative CVR (CVR Results: Twenty-one patients were evaluated (age range 10-61; 16 females), three was excluded due to technical issues. Median RMSE ranged between 2.8 and 3.8 ml/100 g/min. CVR Conclusion: This parameterized gamma-variate function framework provides physiologically interpretable parameters for modelling the CBF response to ACZ in MMD.

Indexed as

AcetazolamideArterial spin labelingCerebral blood flowCerebrovascular reserveModellingMoyamoya

Identifiers

PMID42222270
PMCPMC13218246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.