Evidence map›Paper›PMID 42222219›Full record

ArticleFrontiers in surgery2026

A novel endpoint for liver surgery predicts surgery-related mortality: external validation in a surgical cohort with intrahepatic cholangiocarcinoma.

Constantin Scholz, Evangelos Tagkalos, Franziska Renger, Monia Passalacqua, Lukas Müller, Maximilian Moos, Lisa Katharina Gröger, Jens Mittler, Janine Baumgart, Tobias Huber and 4 more

Abstract read
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In one paragraph

Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Constantin ScholzDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Evangelos TagkalosDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Franziska RengerDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Monia PassalacquaDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Lukas MüllerDepartment of Diagnostic and Interventional Radiology, University Medical Center Mainz, Mainz, Germany.
Maximilian MoosDepartment of Diagnostic and Interventional Radiology, University Medical Center Mainz, Mainz, Germany.
Lisa Katharina GrögerDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Jens MittlerDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Janine BaumgartDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Tobias HuberDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.
Friedrich FoersterDepartment of Internal Medicine, Gastroenterology and Hepatology, University Medical Center Mainz, Mainz, Germany.
Arndt WeinmannDepartment of Internal Medicine, Gastroenterology and Hepatology, University Medical Center Mainz, Mainz, Germany.
Fabian BartschDepartment of General and Visceral Surgery, Hospital "Barmherzige Brüder" Trier, Trier, Germany.
Hauke LangDepartment of General, Visceral and Transplant Surgery, University Medical Center Mainz, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The composite endpoint for liver surgery (CELS) was developed to predict surgery-related mortality and to improve the design of clinical trials in liver surgery. However, external validation beyond the initial development cohort remains limited. This study aimed to assess the validity and reliability of CELS in a distinct patient population undergoing liver resection for intrahepatic cholangiocarcinoma. Methods: The primary objective was to assess the association between CELS and surgery-related mortality. Secondary objectives included 30-day mortality, length of hospital stay (LOS), overall survival, and recurrence-free survival. Predictive performance was evaluated using sensitivity, specificity, accuracy, and receiver operating characteristic curve analyses. Results: A total of 227 patients were included in the analysis (CELS-positive: Conclusions: CELS demonstrated moderate predictive ability for surgery-related mortality following liver resection for intrahepatic cholangiocarcinoma.

Indexed as

clinical studycomposite endpointendpointshepatectomyintrahepatic cholangiocarcinomaliver surgerypostoperative complicationsvalidation study

Identifiers

PMID42222219
PMCPMC13218855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.