Evidence map›Paper›PMID 42222209›Full record

ArticleIntegrative medicine (Encinitas, Calif.)2026

Increasing Leukocyte and Neutrophil Count with Vitamin C Supplementation: A Case Report.

Pamela K B Cho, Mary Gordon, Oscar Coetzee

Abstract readCase Reports
In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pamela K B ChoPrivate California-based practice, Clinical Nutrition and Integrative Health, Maryland University of Integrative Health/Notre Dame of Maryland University, CNS candidate.
Mary GordonPrivate Maine-based practice, Clinical Nutrition and Integrative Health, Maryland University of Integrative Health/Notre Dame of Maryland University, CNS candidate.
Oscar CoetzeeProfessor, Notre Dame of Maryland University, Baltimore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current literature details the use of intravenous vitamin C to improve leukopenia; however, the use of oral vitamin C to improve leukopenia has been underexplored. Objective: This case study aimed to evaluate whether supplemental oral vitamin C could elevate leukocyte values in a 67-year-old African American male. Case Report: The patient had leukopenia for over 30 years, which prompted additional medical evaluation over the years. This evaluation included two bone marrow biopsies, both of which yielded normal findings. Although the individual was not traumatized by the medical concern and extensive testing for his neutropenia, he wanted to explore whether vitamin C could address his leukopenia. Over the course of one year, the individual took 5000-7000 mg of vitamin C daily in powdered and liposomal forms. Findings: 5000 - 7000 mg of vitamin C successfully increased white blood cell count (near the standard normal limits) and absolute neutrophil count in the African American male patient. Conclusion: This case report details the use of supplemental oral vitamin C as a single intervention to improve leukopenia and neutropenia. However, more research is needed to determine if smaller doses could yield similar results.

Indexed as

African Americancase reportleukopenianeutropeniavitamin Cwhite blood cell production

Identifiers

PMID42222209
PMCPMC13218808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.