ArticleFrontiers in pharmacology2026
Development of a core outcome set for traditional Chinese medicine for atrial fibrillation.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
Objectives: The inconsistent reporting of clinical trial results in patients with atrial fibrillation (AF) hinders the comparison of findings. Developing a core outcome set (COS) in studies evaluating traditional Chinese medicine (TCM) for AF and recommending measurement instruments and time points may help standardize the selection, reporting, and measurement of outcomes in clinical trials. Methods: Literature and registered trials were retrieved to systematically collect outcomes. Physician questionnaire surveys and semi-structured patient interviews were conducted to collect outcomes of clinical interest. These outcomes were standardized and compiled into a preliminary outcome pool. Consensus criteria were established in advance. Through two rounds of Delphi surveys and consensus meetings, perspectives from multiple stakeholder groups were gathered to establish a COS for TCM for AF (COS-TCM-AF). Results: A total of 87 individuals participated in the Delphi survey, with 70 completing both rounds. During the consensus meeting, 19 stakeholders determined that seven core outcomes should be involved in the COS-TCM-AF, including AF episode frequency, AF episode duration, AF burden, TCM symptom-palpitation, thromboembolic (TE) event rate, AF recurrence rate, and incidence of acute heart failure (HF)/acute exacerbation of chronic HF. Among these, AF episode frequency and AF episode duration applied only to patients with paroxysmal AF. Conclusion: This COS comprehensively addresses multiple aspects including AF episodes, patient symptoms, complication risks and long-term prognosis. It also recommends measurement instruments and time points. Its implementation will contribute to facilitating the comparison of similar studies and provide a reference for selecting and measuring outcomes.
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