ArticleFrontiers in pharmacology2026
Deutscher Arzneimittel-Codex-aligned multi-dimensional quality assessment of Gastrodiae Rhizoma granules.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Reproducible quality assessment is essential for the standardization and international comparability of herbal granule products. Gastrodiae Rhizoma granules (GRG) are widely used herbal preparations, yet analytical strategies aligned with different compendial requirements remain limited. The study aimed to establish and evaluate a Deutscher Arzneimittel-Codex (DAC)-aligned analytical strategy for the quality assessment of GRG and compare it with the Chinese national standard. Methods: A multi-dimensional analytical approach integrating thin-layer chromatography (TLC), quantitative analysis of multi-components by single marker (QAMS), and high-performance liquid chromatography (HPLC) fingerprinting was developed for GRG. TLC was assessed using DAC system suitability requirements. Gastrodin was used as the internal reference for simultaneous determination of Results: The TLC method achieved clear separation of gastrodin and parishin B, satisfying DAC suitability requirements. QAMS results showed no significant difference ( Conclusion: This study demonstrates the feasibility of a DAC-aligned analytical strategy for the multi-dimensional quality assessment of GRG, and offers a useful reference for cross-standard comparison and for the harmonization of quality evaluation approaches of herbal granule products.
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