Trial reportF1000Research2025
Shining Light into Adolescent HIV Neuroplasticity: A Study of the Prefrontal Cortex Using Functional Near Infrared Spectrometry.
Trial report in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The human immunodeficiency virus (HIV) crosses the blood-brain barrier, compromising cortical networks and cognition. Neuropharmacological intervention in the form of combination antiretroviral therapy (cART) does not reverse cognitive decline in pediatric and adolescent HIV. In search of options to enhance cognition in affected adolescents, we evaluated the effectiveness of attention training. Methods: The training was evaluated by pairing participants' outcomes on the Stroop Colour Word Test (SCWT), a test of attention and inhibitory control, to brain hemodynamic responses measured by functional near-infrared spectrometry (fNIRS) both prior to, and after, the training. Changes in oxygenated haemoglobin in the prefrontal cortex during the SCWT were compared in 15 HIV+ participants who received attention training with that of 13 HIV+ participants who did not receive the intervention. Results: Intragroup analyses showed differences in oxygenated haemoglobin levels between congruent and incongruent conditions of the SCWT only for participants who received the attention training. Specifically, improved behavioural performance on SCWT for the attention group was associated with a significant decrease in oxygenated haemoglobin in the dorsolateral prefrontal cortex, and frontopolar brain areas in the training group. Decreased hemodynamic activation in the training group suggests greater neural efficiency in completing cognitive tasks. Conclusions: Findings suggest that customised attention training maybe an effective complementary adjunct to cART for children and adolescents living with HIV.
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