Evidence map›Paper›PMID 42222120›Full record

ArticleFrontiers in cardiovascular medicine2026

Differential associations of cooking behaviors with polycyclic aromatic hydrocarbon exposure-related platelet traits as cardiovascular risk biomarkers.

Quanping Yan, Yaoyao Li, Sheng Wang, Xiaohuan Yang, Ziyuan Zhang, Yinghao Yuchi, Chongjian Wang, Ge Zhao, Fuwei Xie

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Quanping Yan *Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Yaoyao Li *Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Sheng WangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Xiaohuan YangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Ziyuan ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Yinghao YuchiDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Chongjian WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Ge ZhaoKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Fuwei XieKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Polycyclic aromatic hydrocarbons (PAHs) typically occur as mixtures, and their combined associations with platelet traits have been scarcely explored in rural populations. This study investigated both individual and joint associations of PAHs with platelet traits. Methods: A subpopulation ( Results: GLM showed that there were associations of certain plasma PAHs with platelet traits across participants. For instance, Dibenz(a,h)anthracene (DahA), Fluoranthene (Flu), and Pyrene (Pyr) were negatively associated with platelet count (PLT) in the total population. Positive associations of certain PAHs with platelet size indicators such as MPV and platelet distribution width (PDW) were observed. The mixture of 10 PAHs was positively associated with PDW, MPV, platelet large cell ratio, MPV/PLT ratio (MPVP), and PDW/PLT, with DahA and Benzo(a)pyrene (BaP) identified as major contributors. These associations remained among non-smoking and non-cooking men and non-smoking women who reported self-cooking. Discussion: The findings show that individual plasma PAHs and their mixture are related to increased risk of platelet dysfunction, with BaP and DahA identified as key contributors. The results indicate that the association between PAH exposure and changes in platelet indicators was prominent among women with unhealthy cooking behaviors.

Indexed as

henan rural cohort studyplatelet distribution widthplatelet indicatorspolycyclic aromatic hydrocarbonsquantile g-computation

Identifiers

PMID42222120
PMCPMC13218849

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