ArticleFrontiers in endocrinology2026
Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Erythritol is a widely used non-nutritive sweetener generally regarded as safe. However, recent emerging evidence has begun to reveal potential adverse effects, including possible associations with cancer and cardiovascular disease. Nevertheless, its potential impact on female reproductive health remains largely unexplored. Methods: The present study investigated the transgenerational effects of gestational erythritol exposure on ovarian morphology and molecular signaling in Wistar rats. Pregnant females were administered 0.4 or 4 g/kg/day of erythritol from gestational day 6 until parturition. Ovarian histopathological architecture along with oxidative stress and molecular signaling markers were evaluated in F1 and F2 female offspring at the prepubertal stage. Results: We found that Discussion: Collectively, these findings demonstrate that gestational erythritol exposure promotes oxidative stress, disrupts autophagy, impairs steroidogenesis, and inhibits PI3K signaling, culminating in transgenerational ovarian dysfunction.
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