Evidence map›Paper›PMID 42222056›Full record

ArticleFrontiers in cellular neuroscience2026

Perinatal mAChR-mediated activation of cortical subplate neurons elicits network activity driving basket cell differentiation.

Petra Wahle, Michelle Kaczmarski, Christian Riedel, Mohammad I K Hamad, Olga Arne, Erwan Dupont, Alexander Jack, Lisa-Marie Rennau, Andrea Räk, Heiko J Luhmann and 2 more

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Petra WahleDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Michelle KaczmarskiDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Christian RiedelDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Mohammad I K HamadDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Olga ArneDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Erwan DupontInstitute of Physiology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Alexander JackDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Lisa-Marie RennauDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Andrea RäkDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Heiko J LuhmannInstitute of Physiology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Ina KöhlerDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.
Silke PatzDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activation of mAChR on subplate neurons has been shown to trigger oscillatory glutamatergic network activity in early postnatal neocortex. Here, we explored the long-term consequences of subplate activation on the differentiation of cortical neurons. Stimulating newborn somatosensory and visual cortex ex vivo and organotypic cortex cultures (OTCs) of the visual cortex with carbachol (CCH) led to an upregulation of

Indexed as

axogenesisaxon-carrying dendritesdendritogenesisfast-spiking and regular-spiking inhibitory neuronspyramidal cell dendrites and spines

Identifiers

PMID42222056
PMCPMC13215935

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.