ArticleResuscitation plus2026
Age-dependent neuroprotection and inflammatory responses to mild therapeutic hypothermia following cardiac arrest.
Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To investigate age-related differences in the neuroprotective effects and mechanisms of mild therapeutic hypothermia (MTH) after cardiac arrest (CA) to inform age-specific therapeutic strategies. Methods: Overall, 660 patients after CA were selected from the clinical databases for further validation analysis using a random forest model. 183 male rats underwent 6-min asphyxia CA and were randomized into adult (12-16 weeks) or aged (76-84 weeks) groups: sham (without CA, 37°C), sham + MTH (without CA, 33°C for 2 h), control (induced CA, 37°C), and MTH (induced CA, 33°C for 2 h). Over a 5-day post-return of spontaneous circulation (ROSC) period, survival, neurological function (deficit scores and locomotor activity), interleukin (IL)-17/IL-6 levels (serum and hippocampus), and CA1 neuronal apoptosis were evaluated. Results: Clinical data analysis identified a significant interaction between age and MTH in predicting survival probability ( Conclusion: Aged rats showed no benefit from MTH in survival, function, or inflammation compared to adult rats. Age alters the neuroprotective and anti-inflammatory effects of MTH after CA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.