ReviewCancer management and research2026
A Review of the Role and Mechanism of GNG4 Gene Expression in the Tumor Microenvironment Across Broad Spectrum of Tumor Types.
Review in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
DNA methylation is a common and very important type of epigenetic modification, and its changes often occur in cancer and are highly dysregulated. Guanine Nucleotide binding-protein Gamma subunit 4 (GNG4), as a key component of the G protein-coupled receptor (GPCR) signaling pathway, its methylation is closely related to the occurrence and development of various tumors. The immuno-suppressive state and component remodeling of the tumor microenvironment (TME) are the core driving factors for tumor progression, and GNG4 plays a-dimensional role in regulating TME by regulating signaling pathway activity, immune cell infiltration and microenvironmental physical and chemical characteristics. This review comprehensively summarizes the expression pattern of GNG4 in different tumors, analyzes its regulatory mechanism on immune cells, signaling molecules and pathological characteristics in TME, and explores its clinical potential as a prognostic marker and therapeutic target providing references for broad spectrum of tumors research and precision treatment.
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