Evidence map›Paper›PMID 42221982›Full record

ReviewNeuro-oncology advances2026

Vertebral metastatic disease: A paradigm shift.

Annee Nguyen, Trupti Trivedi, Ellen O'Callaghan, Seeley Yoo, Tanner Zachem, Ramzy Ahmed, Rafael De La Garza Ramos, Raphaele Charest-Morin, Mark H Bilsky, Daniel Sciubba and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Annee NguyenDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).
Trupti TrivediDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).
Ellen O'CallaghanDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).
Seeley YooDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).
Tanner ZachemDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).
Ramzy AhmedDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).
Rafael De La Garza RamosDepartment of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine, New York (R.D.L.G.R.).
Raphaele Charest-MorinDivision of Spine, Department of Orthopaedics, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada (R.C.-M.).
Mark H BilskyDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York (M.H.B., O.B.).
Daniel SciubbaNorth Health, North Shore University Hospital and Long Island Jewish Medical Center, Great Neck (D.S.).
Michelle ClarkeDepartment of Neurosurgery, Mayo Clinic Rochester, Rochester (M.C.).
Claudio TatsuiDepartment of Neurosurgery, Division of Surgery, MD Anderson Cancer Center, Houston (C.T.).
John H ShinDepartment of Neurosurgery, Penn Medicine, Philadelphia (J.H.S.).
Ilya LauferDepartment of Neurosurgery, NYU Langone Health, New York (I.L.).
Ori BarzilaiDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York (M.H.B., O.B.).
Ziya L GokaslanDepartment of Neurosurgery, Brown University, Providence (Z.L.G.).
Arjun SahgalDepartment of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada (A.S.).
Michael WeberDepartment of Orthopedics & Sports Medicine in Spine, University of Connecticut Health Center, Farmington (M.W.).
Patricia Leigh Zadnik SullivanDepartment of Neurosurgery, Brown University Health, Providence (P.L.Z.S.).
Nicolas DeaDivision of Neurosurgery, University of British Columbia, Vancouver, British Columbia, Canada (N.D.).ORCID https://orcid.org/0000-0002-3404-8059
Áron LazáryNational Center for Spinal Disorders, Budapest, Hungary (A.L.).
Trey MullikinDepartment of Radiation Oncology, Duke University School of Medicine, Durham (T.M.).
C Rory GoodwinDepartment of Neurosurgery, Duke University School of Medicine, Durham (A.N., T.T., E.O.C., S.Y., T.Z., R.A., C.R.G.).ORCID https://orcid.org/0000-0002-6540-2751

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FRANCESCA M GANY · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Vertebral metastatic disease results from many types of cancer and can have a devastating impact on patient mobility, psychological health, quality of life, and ultimately overall patient survival. However, the development of radiotherapy and surgical techniques has rapidly surged in conjunction with ongoing advances in basic science and translational studies. In this review, we discuss the paradigm shift in our understanding of the epidemiology and treatment algorithms for spinal oncology, ranging from preoperative optimization strategies, radiation and surgical techniques, the utilization of molecular markers and targeted therapeutics in medical oncology, and prognostication tools that underscore a new multidisciplinary approach to spinal oncology care.

Indexed as

genomicsradiation oncologyspine metastasesspine oncologysurgery

Identifiers

PMID42221982
PMCPMC13221133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.