Evidence map›Paper›PMID 42221954›Full record

ArticleFrontiers in veterinary science2026

Enhancing phagocytic capacity in layer chickens: a one health approach to sustainable production through improved disease resistance and reduced antibiotic dependence.

Shunqi Liu, Jingchao Cao, Shuqi Wang, Shiyu Qi, Yue Zhao, Shoulong Deng, Zhichao Sun, Wendi Zhou, Kun Yu, Yitong Yuan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shunqi Liu *Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Jingchao Cao *Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Shuqi WangNational Animal Husbandry Services, Beijing, China.
Shiyu QiCollege of Animal Husbandry and Veterinary Medicine, Jinzhou Medical University, Jinzhou, Liaoning, China.
Yue ZhaoBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Shoulong DengBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Zhichao SunShandong Aijia Poultry and Livestock Co., Ltd., Liaocheng, Shandong, China.
Wendi ZhouBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Kun YuBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yitong YuanDepartment of Laboratory Animal Center, Shanxi Medical University, Taiyuan, Shanxi, China.
Zhengxing LianBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reducing antibiotic dependence in poultry production is critical to mitigating antimicrobial resistance (AMR). Selective breeding for stronger innate immunity may provide a sustainable alternative under a One Health framework. This study investigates whether enhancing monocyte/macrophage phagocytic capacity in layer chickens could improve disease resistance without compromising production performance under antibiotic-free conditions. Methods: Phagocytic capacity was assessed using multiple assays. Phagocytosis product (PP) was measured using the MTT-HCT-8 method, pHrodo-labeled Results: PP measured by the MTT-HCT-8 method was significantly correlated with PP or PI using the other methods ( Conclusion: Selecting for proper high phagocytic capacity (with a preliminary estimated PP range of 1.58-2.74) improves resistance in layer chickens reared antibiotic-free without reducing productivity and exacerbating oxidative stress or inflammation. These findings support phagocytosis-based phenotyping as a potential balanced-breeding strategy consistent with One Health goals for sustainable poultry production.

Indexed as

antibiotic-free rearingdisease resistancelayermonocyte/macrophagephagocytosis product

Identifiers

PMID42221954
PMCPMC13215808

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.