Evidence map›Paper›PMID 42221917›Full record

ArticleClinical and translational radiation oncology2026

Limb-sparing reconstruction using extracorporeal irradiation and autograft recycling for primary malignant bone tumors.

Edona Dreshaj, Nicolas Danthez, Fernanda G Herrera, David Patin, Maud Marguet, Antonia Digklia, Ana Dolcan, Giovanni Dei Tos, Gilles Udin, Stéphane Cherix and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edona DreshajFaculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Nicolas DanthezDepartment of Oncology, Radio-Oncology Service, Lausanne University Hospital, Switzerland.
Fernanda G HerreraFaculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
David PatinInstitute of Radiation Physics, Lausanne University Hospital, Switzerland.
Maud MarguetInstitute of Radiation Physics, Lausanne University Hospital, Switzerland.
Antonia DigkliaDepartment of Oncology, Radio-Oncology Service, Lausanne University Hospital, Switzerland.
Ana DolcanDepartment of Oncology, Radio-Oncology Service, Lausanne University Hospital, Switzerland.
Giovanni Dei TosDepartment of Oncology, Radio-Oncology Service, Lausanne University Hospital, Switzerland.
Gilles UdinDepartment of Orthopedics and Traumatology, Lausanne University Hospital, Switzerland.
Stéphane CherixFaculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Rémy KinjFaculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Autograft recycling (AR) using extracorporeal irradiation (ECI) enables limb-sparing reconstruction following resection in patients with primary malignant bone tumors (MBTs). We evaluated the oncological and functional outcomes after this procedure in a single-institution cohort. Materials and methods: This retrospective cohort study included patients with MBTs treated between December 2016 and February 2024 with en-bloc resection, AR using a single fraction of 50 Gy ECI, and bone reimplantation. Results: Twenty patients were included, with a median age of 38 years (min-max range, 18-80). The predominant histological subtypes were chondrosarcoma (N = 10), osteosarcoma (N = 4), and Ewing's sarcoma (N = 3). The pelvis was the most frequently treated site (N = 11), followed by the upper limbs (N = 5) and the lower limbs (N = 3). All patients underwent en-bloc resection followed by a single fraction of 50 Gy ECI and reimplantation of the bone. Median follow-up was 17.1 months (min-max range, 2.5-80.6). The 2 years overall survival (OS) rate was 94.4% (Cl 95%, 83.8-100). Local control at 1 year and 2 years was 100% (Cl 95%, 100-100), and 62.5% (Cl 95%, 29.1-96.1). Functional outcomes were graded as good to excellent in 12 patients (60%) and fair to poor for 8 patients (40%). In multivariate analysis, a larger tumor size was significantly associated with local relapse (p = 0.02), while re-interventions were negatively associated with OS (p = 0.026). Conclusion: AR using ECI achieved encouraging oncological and functional outcomes in patients with MBTs and represents a valuable reconstructive technique in limb-sparing surgery.

Indexed as

Autograft recyclingBone sarcomaChondrosarcomaEwing sarcomaExtracorporeal irradiation

Identifiers

PMID42221917
PMCPMC13217923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.