Evidence map›Paper›PMID 42221863›Full record

ArticleIEEE access : practical innovations, open solutions2026

Learning to Diagnose Privately: DP-Powered LLMs for Radiology Report Classification.

Payel Bhattacharjee, Fengwei Tian, Geoffrey D Rubin, Joseph Y Lo, Nirav Merchant, Heidi A Hanson, John Gounley, Ravi Tandon

Abstract read
In one paragraph

Article in IEEE access : practical innovations, open solutions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Payel BhattacharjeeDepartment of Electrical and Computer Engineering, The University of Arizona, Tucson, AZ 85719, USA.ORCID 0009-0006-7506-8300
Fengwei TianDepartment of Electrical and Computer Engineering, The University of Arizona, Tucson, AZ 85719, USA.ORCID 0009-0007-9850-0028
Geoffrey D RubinDepartment of Radiology and Imaging Sciences, The University of Arizona, Tucson, AZ 85724, USA.
Joseph Y LoDepartment of Radiology and Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-9540-5072
Nirav MerchantData Science Institute, The University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-1988-8180
Heidi A HansonOak Ridge National Laboratory, Oak Ridge, TN 37830, USA.ORCID 0000-0003-0056-196X
John GounleyOak Ridge National Laboratory, Oak Ridge, TN 37830, USA.ORCID 0000-0001-8424-4982
Ravi TandonDepartment of Electrical and Computer Engineering, The University of Arizona, Tucson, AZ 85719, USA.ORCID 0000-0002-6182-6098

Funding

Computer-Aided Triage of Body CT Scans with Deep LearningR01CA261457 · NCI · DUKE UNIVERSITY · PI LO, JOSEPH Y, RUBIN, GEOFFREY D · 2023 to 2025
$2.3M
NCI NIH HHS R01 CA261457
6 · The paper itself

Abstract

Large Language Models (LLMs) are being widely adopted in different domains including education, healthcare, and finance. In healthcare domain, LLMs are used in disease diagnosis, abnormality classification, remedy suggestions etc. Multi-abnormality classification of radiology reports is essential in healthcare, medical decision-making, and drug discovery. LLMs are increasingly utilized for such tasks because of their remarkable Natural Language Processing (NLP) capabilities, which streamline medical report processing and reduce administrative burden. To enhance the predictive accuracy, LLMs are often fine-tuned on private, locally available datasets, such as medical reports. However, this practice raises significant privacy concerns, as LLMs are prone to memorizing training data, making them susceptible to data extraction attacks even through query-based access. Additionally, sharing fine-tuned models and weights poses adversarial risks, because they may inadvertently reveal sensitive information about the training data. Despite the growing application of LLMs to medical text classification, privacy-preserving fine-tuning for multi-abnormality classification remains underexplored. To bridge this gap, we propose a differentially private (DP) fine-tuning approach that preserves privacy while enabling multi-abnormality classification from text radiology reports through Low Rank Adaptation (LoRA). Our framework leverages DP optimization techniques to fine-tune LLMs on local patient data while mitigating data leakage risks. To our knowledge, this is the first study to incorporate DP fine-tuning of LLMs for multi-abnormality classification using text-based radiology reports. We used labels generated by a larger LLM to fine-tune a smaller LLM, accelerating inference while maintaining privacy constraints. We conducted extensive experiments on the MIMIC-CXR, and CT-RATE datasets to evaluate DP fine-tuning method across varying privacy regimes, analyzing the privacy-utility trade-off and demonstrating the efficacy of our approach. For instance, on the MIMIC-CXR dataset, our proposed DP-LoRA framework achieves weighted F1-scores of up to 0.89 under moderate privacy budgets (

Indexed as

chest radiology reportsDifferential privacylarge language modelsmulti-abnormality classificationnatural language processing

Identifiers

PMID42221863
PMCPMC13218749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.