Evidence map›Paper›PMID 42221823›Full record

ArticleiScience2026

An NT5E loss-of-function variant permits tissue inflammation and hypertension in systemic lupus erythematosus.

Isaac Peabody, Mikhail Olferiev, Katherine A Owen, Tyson Dawson, Prathyusha Bachali, Peter Kasson, Amrie C Grammer, Mary K Crow, Peter E Lipsky

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isaac PeabodyAMPEL Biosolutions, LLC and the RILITE Research Institute, Charlottesville, VA 22902, USA.
Mikhail OlferievMary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY 10021, USA.
Katherine A OwenAMPEL Biosolutions, LLC and the RILITE Research Institute, Charlottesville, VA 22902, USA.
Tyson DawsonAMPEL Biosolutions, LLC and the RILITE Research Institute, Charlottesville, VA 22902, USA.
Prathyusha BachaliAMPEL Biosolutions, LLC and the RILITE Research Institute, Charlottesville, VA 22902, USA.
Peter KassonDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Amrie C GrammerAMPEL Biosolutions, LLC and the RILITE Research Institute, Charlottesville, VA 22902, USA.
Mary K CrowMary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY 10021, USA.
Peter E LipskyAMPEL Biosolutions, LLC and the RILITE Research Institute, Charlottesville, VA 22902, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine, generated by CD73/NT5E, is a critical endogenous regulator of immune-mediated inflammation. Genetic variants in

Indexed as

immunologymolecular geneticsomics

Identifiers

PMID42221823
PMCPMC13217859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.