ArticleFrontiers in nutrition2026
Intermittent fasting alleviates irradiation-induced neuronal mitochondrial damage in mice.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purposes: Radiation-induced brain injury (RIBI) is a common side effect of cranial radiotherapy. Intermittent fasting (IF) decreases the risk of Brain aging disease by affecting mitochondrial function. We examined the effects of IF on mitochondrial function, neurogenesis, morphology of hippocampal neurons and cognitive abilities in a whole-brain radiotherapy (WBRT) mouse model. Methods: 6-8 weeks old male C57BL/6J mice received 10 Gy WBRT. IF group mice were subjected to cycles of 24 h food restriction followed by 48 h Results: The proportion of swollen mitochondria in hippocampal neurons was significantly decreased in the IF+WBRT group than the WBRT ( Conclusions: IF mitigates RIBI by reducing mitochondrial damage, promoting neurogenesis, and partially restoring ATP levels at the early stage, although its behavioral effects remain limited. The beneficial effect of IF is time-dependent and more prominent in the acute phase of RIBI.
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