Evidence map›Paper›PMID 42221745›Full record

ArticleCommunications materials2026

Antibody-conjugated species-sorted single-walled carbon nanotubes for multiplexed cytokine sensing.

Amelia K Ryan, Sadiyah Parveen, Zachary Cohen, Atara Israel, Ryan M Williams

Abstract read
In one paragraph

Article in Communications materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amelia K RyanThe City College of New York, Department of Biomedical Engineering, New York, NY, USA.
Sadiyah ParveenThe City College of New York, Department of Biomedical Engineering, New York, NY, USA.
Zachary CohenThe City College of New York, Department of Biomedical Engineering, New York, NY, USA.
Atara IsraelThe City College of New York, Department of Biomedical Engineering, New York, NY, USA.
Ryan M WilliamsThe City College of New York, Department of Biomedical Engineering, New York, NY, USA.

Funding

Research Center in Minority Institutions (RCMI) at City CollegeU54MD017979 · NIMHD · CITY COLLEGE OF NEW YORK · PI M. Felice Marina GHILARDI · 2024 to 2026
$15.9M
G-RISE: Graduate Research Initiative for Student Advancement at The City College of New YorkT32GM136499 · NIGMS · CITY COLLEGE OF NEW YORK · PI RUTH E. STARK · 2020 to 2026
$4.9M
Integrating Real-Time Multi-System Cytokine Signaling in Chronic DiseaseR35GM142833 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI WILLIAMS, RYAN MARTIN · 2021 to 2025
$2.4M
NIGMS NIH HHS R35 GM142833NIGMS NIH HHS T32 GM136499NIMHD NIH HHS U54 MD017979
6 · The paper itself

Abstract

Single-walled carbon nanotubes (SWCNT) are versatile building blocks for optical sensors. Their near infrared photoluminescent emission is determined by their chiral structure. Commercially available SWCNT are polydisperse, leading to spectral congestion and no ability single analyte sensing. Aqueous two-phase extraction (ATPE) is a technique to sort SWCNT structures for improved nanosensor performance and multiplexed sensing. To date, ATPE has not been demonstrated with bioconjugate-compatible surface chemistries. Here, we demonstrate improved and multiplexed cytokine sensing by ATPE sorting SWCNT species with amine-functionalized ssDNA. We show that this approach enables effective chirality sorting and direct antibody conjugations. We used sorted, functionalized SWCNT to simultaneously and specifically detect the inflammatory cytokines IL-12 and IL-6 with high sensitivity and selectivity, and improved robustness compared to unsorted SWCNT. We anticipate that such sensitive, multiplexed will be useful for implantable and bedside diagnostics of inflammatory processes while serving as a model for sensing other complex biological processes.

Indexed as

chiralityinflammationmultiplexsensorsSingle-walled carbon nanotube

Identifiers

PMID42221745
PMCPMC13221203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.