Evidence map›Paper›PMID 42221704›Full record

ArticleNAR molecular medicine2026

Evolutionary refinement of the ZIKV 5' UTR dictates a trade-off between RNA stability and promoter accessibility.

Alex B Wang, Quinn H Abram, Carolina Camargo, Trisha R Barnard, Selena M Sagan

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In one paragraph

Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alex B WangDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Quinn H AbramDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Carolina CamargoDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Trisha R BarnardDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5107, United States.
Selena M SaganDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID https://orcid.org/0000-0002-8484-3632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) has evolved from a sporadically circulating pathogen into a global health threat associated with severe neurological complications. While research has been focused on amino acid substitutions, the impact of non-coding RNA evolution on ZIKV fitness remains largely unexplored. Here, we characterize the structural and functional evolution of stem-loop A (SLA), the essential 5' terminal promoter for the viral polymerase. We identified four distinct evolutionary variants, ancestral (Anc), intermediate (Int), contemporary (Con), and alternative (Alt) that exhibit a progressive shift in thermodynamic stability. Notably, SLA

Identifiers

PMID42221704
PMCPMC13221642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.