ArticleFrontiers in public health2026
Low oxygen content as a potential risk factor for scoliosis: a school-based cross-sectional study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Scoliosis is a complex three-dimensional spinal deformity. While its clinical and imaging features are well established, the exact etiology and pathogenesis remain unclear. Previous studies have identified altitude as a significant environmental factor associated with scoliosis development. High-altitude regions are characterized by lower oxygen levels, raising the question of whether hypoxia contributes to the higher prevalence of scoliosis observed in these areas. Methods: This cross-sectional study used school-based scoliosis screening data. Individuals with an angle of trunk rotation (ATR) ≥ 5° were recorded as positive cases. Demographic information and regional environmental data were collected. Statistical analyses were conducted to identify risk factors associated with scoliosis. Results: The positive screening rate was 1.9%. Females and adolescents aged 10-18 years had significantly higher positivity rates than males and younger children (both Conclusion: Lower ambient oxygen content is associated with higher scoliosis screening positivity.
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