Evidence map›Paper›PMID 42221587›Full record

ArticleFrontiers in cellular and infection microbiology2026

Disruption of chitin synthases impairs tick feeding and reproduction, validating a broad-spectrum acaricide target.

Ondrej Hajdusek, Veronika Urbanova, Martin Moos, Marie Vancová, Jan Perner

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ondrej HajdusekInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia.
Veronika UrbanovaInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia.
Martin MoosInstitute of Entomology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia.
Marie VancováInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia.
Jan PernerInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chitin, a major structural component of arthropods, is synthesized by chitin synthases (CHSs), which polymerize N-acetylglucosamine and extrude chitin into the extracellular matrix. CHSs are essential for cuticle formation and peritrophic matrix (PM) biogenesis and represent validated targets of several acaricides, yet their roles in ticks remain poorly defined. Here, we functionally characterize CHSs in the tick

Indexed as

AcaricidesChitin SynthaseFeeding BehaviorIxodesAnimalsChitinFemaleGene Expression ProfilingRNA InterferenceAcaricidesChitinChitin SynthaseacaricideBorreliachitinchitin synthaseetoxazoleresistanceRNAitick

Identifiers

PMID42221587
PMCPMC13219254

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.