Evidence map›Paper›PMID 42221574›Full record

ArticleBrain communications2026

Early-life blood pressure and midlife brain and cognitive health: tests in two birth cohorts.

Mayibongwe Mugoba, Renate M Houts, Annchen R Knodt, Reremoana F Theodore, Richie Poulton, Ahmad R Hariri, Avshalom Caspi, Terrie E Moffitt, Scott T Chiesa

Abstract read
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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mayibongwe MugobaDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London WC1E 7HB, UK.ORCID https://orcid.org/0009-0001-8056-7677
Renate M HoutsDepartments of Psychology and Neuroscience, and Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27708, USA.
Annchen R KnodtDepartments of Psychology and Neuroscience, and Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27708, USA.
Reremoana F TheodoreDunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin 9016, New Zealand.
Richie PoultonDunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin 9016, New Zealand.
Ahmad R HaririDepartments of Psychology and Neuroscience, and Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27708, USA.
Avshalom CaspiDepartments of Psychology and Neuroscience, and Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27708, USA.ORCID https://orcid.org/0000-0003-0082-4600
Terrie E MoffittDepartments of Psychology and Neuroscience, and Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27708, USA.
Scott T ChiesaDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London WC1E 7HB, UK.ORCID https://orcid.org/0000-0003-4323-2189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated blood pressure (BP) in midlife is a well-established risk factor for impaired brain health and cognitive ability in old age. We hypothesized that exposure to elevated BP within the first five decades of life may contribute to this risk through impacts on brain health and/or cognitive ability evident by midlife. Participants (

Indexed as

BCS70blood pressurebrain healthcognitionDunedin

Identifiers

PMID42221574
PMCPMC13218384

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.