Evidence map›Paper›PMID 42221573›Full record

ArticleACS central science2026

A Rigid Supramolecular Solution to a Flexible Problem: A Multifunctional Calix[4]arene-Based Strategy to Prevent α‑Synuclein Toxicity.

Davide Dell'Accantera, Giulia Piccinini, Cristina Ciabini, Isabella C Felli, Stefano Volpi, Nelson Marmiroli, Francesco Sansone, Roberta Ruotolo

Abstract read
In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Davide Dell'AccanteraDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0002-7986-2038
Giulia PiccininiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Cristina CiabiniMagnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
Isabella C FelliMagnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.ORCID https://orcid.org/0000-0002-6018-9090
Stefano VolpiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0002-1914-2338
Nelson MarmiroliConsorzio Interuniversitario Nazionale per le Scienze Ambientali (CINSA), University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0001-9261-4699
Francesco SansoneDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0003-0531-9865
Roberta RuotoloDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0002-5895-8006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathological aggregation of α-synuclein (syn) is a hallmark of Parkinson's disease (PD) and related synucleinopathies. In the present study, we report a supramolecular strategy to reduce syn aggregation and its associated cellular toxicity using a panel of rationally designed anionic calix[4]-arenes. Among them,

Identifiers

PMID42221573
PMCPMC13220195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.