Evidence map›Paper›PMID 42221546›Full record

ArticleMolecular therapy. Nucleic acids2026

Multiplex gene editing suppresses random integration of hepatitis B virus DNA in chronically infected liver.

Samuel Slattery, Wenwen Huo, Amena Arif, Jennifer Gordon, Ryo Takeuchi

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samuel SlatteryExcision BioTherapeutics Inc., Watertown, MA, USA.
Wenwen HuoExcision BioTherapeutics Inc., Watertown, MA, USA.
Amena ArifExcision BioTherapeutics Inc., Watertown, MA, USA.
Jennifer GordonExcision BioTherapeutics Inc., Watertown, MA, USA.
Ryo TakeuchiExcision BioTherapeutics Inc., Watertown, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene editing technologies have opened the possibility of directly targeting viral DNA for therapeutic applications. In chronically infected hepatocytes with hepatitis B virus (HBV), covalently closed circular DNA (cccDNA) serves as the master template for viral transcripts and gene products. In the present study, we evaluated anti-HBV multiplex gene editing with the CRISPR-Cas9 endonuclease from

Indexed as

CRISPR-Cas9DNA integrationhepatitis B virusinfectious diseaselipid nanoparticleMT: RNA/DNA editingmultiplex gene editing

Identifiers

PMID42221546
PMCPMC13217490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.