ArticleFrontiers in microbiology2026
Change in the distribution of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Methods: We conducted a retrospective, hospital-observational, cross-sectional study of IPD cases diagnosed between 2016 and 2023 at two public hospitals in Chile. Clinical records and laboratory reports were reviewed to collect demographic, clinical, vaccination, and serotype data from patients with confirmed IPD. Descriptive statistics were used to summarize qualitative variables as frequencies and quantitative variables using measures of central tendency and dispersion. Results: Non-vaccine Discussions: IPD in Chile during 2016-2023 was driven mainly by non-vaccine serotypes and was associated with substantial mortality among adults. These findings suggest a replacement of vaccine serotypes by non-vaccine serotypes and reveal critical deficiencies in the protection of adults against serotypes that cause IPD. Updated serotype surveillance and reassessment of pneumococcal vaccine strategies, including adult immunization policies, are warranted to improve prevention of severe pneumococcal disease in Chile and similar settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.