ArticleInternational journal of women's health2026
A Study of Potential Classes and Trajectories of Psychological Distress in Infertility Patients: A Study Protocol.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Infertility as a multi-dimensional stressor, the heavy burden of disease significantly restricts the release of the reproductive potential of this group, and brings physiological and psychological troubles to a large number of women. Moreover, intense and continuous psychological distress will lead to further serious psychological problems and various mental diseases. However, the longitudinal evolution trajectory of psychological distress and its key influencing factors have not been systematically clarified. This study aims to reveal temporal changes in psychological distress among infertility patients, analyze the probability of transformation and the key influencing factors, and provide a theoretical basis and practical guidance for early and precise psychological distress intervention. Methods: Infertility patients in the gynecological outpatient department of the Affiliated Hospital of Zunyi Medical University from September 2024 to December 2025 were selected as potential study subjects, and the final study subjects were established according to the exclusion criteria. First, potential classes of psychological distress among infertility patients were identified using latent class analysis (LCA), and relevant measures were administered at 3-, 6-, and 12-month intervals after the first data collection from the study subjects. The development trajectory of psychological distress of infertility patients and its correlation analysis were obtained through the data analysis based on latent transition analysis (LTA). Discussion: Early and accurate management of psychological distress in infertile patients is important to help improve their poor outcomes and increase the fertility rate. The results of this study will provide crucial information to better understand the psychological distress, potential classes, and influencing factors in infertility patients. Trial Registration: Observational study, not applicable.
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