ArticleInternational journal of women's health2026
Fertility Preservation and Spontaneous Pregnancy in a Young Woman with Sertoli-Leydig Cell Tumor: A Five-Year Disease-Free Case Report.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sertoli-Leydig cell tumors (SLCTs) are uncommon ovarian sex cord-stromal neoplasms that predominantly affect young women and are frequently associated with hyperandrogenic features. Case Description: A 23-year-old nulliparous woman presented with a left ovarian mass, accompanied by amenorrhea, clinical signs of virilization, and significantly elevated α-fetoprotein levels. Surgical intervention via left salpingo-oophorectomy was performed. Histopathological evaluation confirmed a Stage IA moderately to poorly differentiated SLCT. Postoperative management included adjuvant chemotherapy with the etoposide and cisplatin, along with administration of a gonadotropin-releasing hormone agonist as an adjunctive measure. No evidence of tumor recurrence was observed over a five-year surveillance period. Subsequently, the patient achieved a spontaneous pregnancy and delivered a healthy male neonate via vaginal delivery. Conclusion: This case demonstrates that in young women with stage IA SLCT, fertility-sparing surgery combined with adjuvant chemotherapy and ovarian preservation strategies may be considered feasible in selected patients for five-year disease-free survival and subsequent spontaneous pregnancy.
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