Evidence map›Paper›PMID 42221377›Full record

ReviewCritical care research and practice2026

Comparison of Volatile Anesthesia and Intravenous Anesthesia for Endovascular Thrombectomy in Acute Ischemic Stroke Patients Under General Anesthesia: A Systematic Review and Meta-Analysis.

Marluce Gois de Oliveira, Wellington de Araujo, Leonardo Saraiva Guimaraes de Oliveira, Livia Kneipp Rodrigues, Lucas Area Leao Barreto, Yara Silva Dias, Nathan Pace, Talmage Egan

Abstract readReview
In one paragraph

Review in Critical care research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marluce Gois de OliveiraSchool of Medicine, Pontificia Universidade Catolica do Parana-PUC/PR, Curitiba, Parana, Brazil.ORCID https://orcid.org/0009-0006-2630-0409
Wellington de AraujoDepartment of Neurology, University of Utah-School of Medicine, Salt Lake, Utah, USA.
Leonardo Saraiva Guimaraes de OliveiraDepartment of Anesthesiology, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Livia Kneipp RodriguesDepartment of Anesthesiology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, ufmg.br.ORCID https://orcid.org/0009-0003-4359-8786
Lucas Area Leao BarretoSchool of Medicine, Universidade Federal do Ceara, Fortaleza, Ceara, Brazil.ORCID https://orcid.org/0000-0003-1511-5700
Yara Silva DiasDepartment of Anesthesiology, Hospital Sancta Maggiore, Sao Paulo City, Sao Paulo, Brazil.
Nathan PaceDepartment of Anesthesiology, University of Utah -School of Medicine, Salt Lake, Utah, USA.
Talmage EganDepartment of Anesthesiology, University of Utah -School of Medicine, Salt Lake, Utah, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endovascular thrombectomy (EVT) is a well-established treatment for acute ischemic stroke (AIS). However, the optimal choice of general anesthesia (GA) during this procedure remains uncertain. This study aims to compare the effects of volatile anesthesia (VA) and total intravenous anesthesia (TIVA) on outcomes in AIS patients undergoing EVT. Methods: We conducted a systematic search of PubMed, Embase, and Cochrane databases for studies comparing VA and TIVA in this context. Key outcomes assessed were favorable functional outcome (defined as a Modified Rankin Scale [mRS] 0-2), mortality, successful recanalization (mTICI 2b/3), and intraoperative mean arterial pressure (MAP). A subgroup analysis was also performed for patients with anterior circulation stroke. Results: A total of 568 patients from four observational studies were included, of whom 187 (33%) received TIVA. In the unadjusted analysis, no statistically significant differences were observed between TIVA and VA in terms of favorable functional outcome (OR 1.28; Conclusion: Among AIS patients undergoing EVT, TIVA may lead to improved functional outcome and reduced mortality compared to VA. These findings support the use of TIVA as a potentially more favorable strategy in this context, warranting further prospective trials.

Indexed as

acute ischemic strokeintravenous anesthesiathrombectomyvolatile anesthesia

Identifiers

PMID42221377
PMCPMC13218072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.