Evidence map›Paper›PMID 42221369›Full record

ArticleOpen forum infectious diseases2026

Kinetics of Enteric Pathogen Quantity During Acute Diarrhea in Children in Resource-Limited Settings.

William J Lain, Sarah E Elwood, Jie Liu, Elizabeth T Rogawski McQuade, Gagandeep Kang, Margaret N Kosek, Aldo A M Lima, Pascal O Bessong, Amidou Samie, Rashidul Haque and 10 more

Abstract read
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In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

William J LainDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID https://orcid.org/0009-0009-1891-1711
Sarah E ElwoodDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Jie LiuSchool of Public Health, Qingdao University, Qingdao, China.ORCID https://orcid.org/0000-0003-2658-5249
Elizabeth T Rogawski McQuadeDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-4942-3747
Gagandeep KangDivision of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
Margaret N KosekDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Aldo A M LimaCenter of Biomedicine and Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
Pascal O BessongDepartment of Microbiology, University of Venda, Thohoyandou, South Africa.
Amidou SamieDepartment of Microbiology, University of Venda, Thohoyandou, South Africa.
Rashidul HaqueInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Estomih R MdumaHaydom Global Health Research Centre, Haydom, Tanzania.
Jose Paulo LeiteFundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-8663-3527
Ladaporn BodhidattaDepartment of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Najeeha T IqbalDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Nicola PageCentre for Enteric Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-5845-4417
Ireen KiweluBiotechnology Research Laboratory, Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Zulfiqar A BhuttaDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Tahmeed AhmedInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-4607-7439
Eric R HouptDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
James A Platts-MillsDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-4956-0418

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen quantity kinetics during childhood diarrhea have implications for etiology ascertainment. Using a multisite cohort, we modeled quantitative PCR quantity by symptom duration. Rotavirus had the largest log reduction in quantity by day 7 (-1.98; 95% confidence interval: -2.88, -1.08), followed by

Indexed as

diarrheapathogen quantityqPCR

Identifiers

PMID42221369
PMCPMC13221649

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.