ArticleBasic and clinical neuroscience2025
Effects of
Article in Basic and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Introduction: Cerebral ischemia is one of the leading causes of global mortality and disability in many countries. Damage caused by reperfusion is due to the inflammatory function of the injured tissue. Ischemia-reperfusion causes the formation of oxygen free radicals and other oxidants. The CA1 region of the hippocampus is one of the highly sensitive parts of the brain in ischemia and hypoxia. The Methods: Four groups of 32 male Wistar rats were randomly formed: Control, ischemia, hydroalcoholic extract of black recipient seed, and nano-extract of hydroalcoholic black seed recipient. Ligation of bilateral common carotid arteries induced an ischemia model. Following the behavioral test, brain removal was completed and prepared for Nissl staining and stereological evaluations, along with the expression levels of Results: A considerable rise in the number of viable pyramidal cells was observed in the hydroalcoholic extract and nano-hydroalcoholic extract groups compared to the ischemia group. Conclusion: Transient global I/R remarkably promotes cell death and morphological changes. It appears that the hydroalcoholic extract of
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