Evidence map›Paper›PMID 42221309›Full record

ArticleClinical and experimental hepatology2026

Potential role of NLRP3 genetic polymorphism and gene expression in differentiating causes of neonatal cholestasis.

Fatma Omar Khalil, Salma Abdel Megeed Nagi, Sally Waheed, Shimaa Saad Elkholy, Hala Ahmed Elrefai Khalil, Shimaa Abdelsattar, Abeer Abd Elfattah Ali Elgazzar, Amany E Elashkar

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Article in Clinical and experimental hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fatma Omar KhalilClinical Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Salma Abdel Megeed NagiPediatric Hepatology, Gastroenterology, and Nutrition Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Sally WaheedEpidemiology and Preventive Medicine, National Liver Institute Menoufia University, Shebin El-Kom 32511, Egypt.
Shimaa Saad ElkholyPathology Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Hala Ahmed Elrefai KhalilClinical Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Shimaa AbdelsattarClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Abeer Abd Elfattah Ali ElgazzarClinical Pathology Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Amany E ElashkarClinical Pathology Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the study: It has long been a focus of research to differentiate among the various causes of neonatal cholestasis, particularly biliary atresia (BA) from non-BA. The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome's role in the pathophysiology of BA is becoming increasingly clear. However, animal models served as the foundation for most of this research. As it is important to diagnose BA as early as possible for a favorable prognosis, the current investigation aimed to investigate the function of NLRP3 rs10754558 and Material and methods: The study included 21 patients with BA, 24 patients with neonatal cholestasis due to causes other than BA, and 20 healthy infants as the control group. A clinical evaluation and standard laboratory testing were conducted on each participant. NLRP3 rs10754558 and Results: A significant difference in NLRP3 rs10754558 was observed between the BA and non-BA groups in the general genotype model ( Conclusions: In conclusion, NLRP3 rs10754558 may contribute to non-BA neonatal cholestasis in ways other than by influencing gene expression levels. However, in non-BA patients, NLRP3 expression levels may improve coagulation.

Indexed as

gene expressionneonatal cholestasisNLRP3 genetic polymorphismpattern recognition receptors

Identifiers

PMID42221309
PMCPMC13220240

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