Evidence map›Paper›PMID 42221301›Full record

ArticleResearch (Washington, D.C.)2026

Platelets Orchestrate a Neuroimmune Axis Driving Cutaneous Inflammation and Itch.

Ximin Hu, Fujun Wang, Ting Wang, Yifei Liu, Lei Zhang, Libei Liu, Liang Cao, Shaofeng Pu, Ronghua Yang, Jing Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Platelets Enter the Itch Circuit.Research (Washington, D.C.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ximin HuDepartment of Burn and Plastic Surgery, School of Medicine, the Second Affiliated Hospital of South China University of Technology (Guangzhou First People's Hospital), Guangzhou 510180, China.ORCID https://orcid.org/0000-0003-0119-6394
Fujun WangDepartment of Burn and Plastic Surgery, School of Medicine, the Second Affiliated Hospital of South China University of Technology (Guangzhou First People's Hospital), Guangzhou 510180, China.
Ting WangState Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Shanghai 200000, China.
Yifei LiuState Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Shanghai 200000, China.
Lei ZhangState Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Shanghai 200000, China.
Libei LiuState Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Shanghai 200000, China.
Liang CaoDepartment of Chinese Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi 710038, China.
Shaofeng PuDepartment of Pain Management, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 200000, Shanghai, China.
Ronghua YangDepartment of Burn and Plastic Surgery, School of Medicine, the Second Affiliated Hospital of South China University of Technology (Guangzhou First People's Hospital), Guangzhou 510180, China.
Jing FengState Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Shanghai 200000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelets are traditionally recognized for their roles in hemostasis, but their involvement as active immune modulators in cutaneous neuroimmune signaling remains poorly understood. In this study, we integrated multi-modal genetic and pharmacological strategies to investigate the functional contribution of platelets to skin inflammation and chronic itch. Optogenetic activation of platelets was sufficient to elicit localized skin inflammation, erythema, and robust pruritus, with transcriptomic profiling of lesions showing strong concordance with the clinical signatures of atopic dermatitis (AD). In experimental AD models, platelet depletion markedly reduced scratching behavior, inflammatory cell infiltration, and C-fiber excitability, whereas platelet activation exacerbated these phenotypes. Mechanistically, activated platelets release serotonin [5-hydroxytryptamine (5-HT)], which compromises vascular integrity and facilitates platelet extravasation into the dermis. This "neuroimmune hub" promotes macrophage recruitment and sensitizes

Identifiers

PMID42221301
PMCPMC13216866

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.