ArticleJournal of human immunity2026
Human germline biallelic loss-of-function
Abstract read
In one paragraph
Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy.Journal of human immunity · 2026Article
- Oncostatin M as a Multifunctional Regulator of Breast Cancer Progression: Current Insights and Future Therapeutic Avenues.IUBMB life · 2026Review
Corrections and comments
- Commented on by
- Update of
Authors and funding
50 authors.
Simran Samra *Department of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-8026-3139
Mehul Sharma *Department of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-9591-0415
Julia KörholzDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0001-6313-4434
Yihui LiuLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0009-0006-6425-321X
Alyssa JamesLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-9726-6611
Christina MichalskiDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0001-9093-5325
Pariya YousefiDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0009-0005-6306-6204
Kate L Del BelDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0001-7669-9530
Henry Y LuDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-1645-7748
Ashish A SharmaDepartment of Pathology, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0001-9444-7046
Maja Tarailo-GraovacDepartments of Biochemistry, Molecular Biology and Medical Genetics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0002-4472-8584
Joshua DalmannDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-6450-0536
Lily BuderDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0009-0005-4996-3777
Bhavi ModiDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-1510-5916
Ralf WiedemuthDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID https://orcid.org/0009-0008-3733-5396
Liam GoldingDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-8851-8052
Britt DrögemöllerDepartment of Biochemistry and Medical Genetics, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0002-3348-5855
Géraldine Blanchard-RohnerUnit of Immunology and Vaccinology, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-9974-2172
Christof SengerDepartment of Pathology and Laboratory Medicine, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0009-0009-0976-4860
Wingfield RehmusDepartment of Pediatrics and Dermatology, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0001-9954-5964
Julie S PrendivilleDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0009-0000-4726-1329
Massimo ManginoDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-2167-7470
Colin J RossDepartment of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-1476-7037
Clara D M van KarnebeekEmma Center for Personalized Medicine, Department of Pediatrics and Human Genetics, Amsterdam University Medical Center, Amsterdam Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, Netherlands.ORCID https://orcid.org/0000-0002-2648-8337
Wyeth W WassermanCentre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Vancouver, Canada.ORCID https://orcid.org/0000-0001-6098-6412
Sergio D RosenzweigImmunology Service, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-5550-9678
Julie NiemelaImmunology Service, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-4197-3792
Pascal M LavoieDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-2205-0362
P M PrathibhaDepartment of Dermatology, Narayana Hrudayalaya Hospital, Mazumdar-Shaw Medical Center, Bangalore, India.ORCID https://orcid.org/0009-0001-4846-2867
Oliver WegehauptCenter for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, Institute for Immunodeficiency, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-9391-0761
Catherine M BiggsDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-4363-2660
Michael BoehnkeDepartment of Biostatistics, Center of Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-6442-7754
Leena KinnunenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID https://orcid.org/0009-0006-8120-8250
Heikki A KoistinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID https://orcid.org/0000-0001-7870-070X
Margaret L McKinnonDepartment of Medical Genetics, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-3161-414X
Jonas Maximillian BreuerPediatric Pulmonology and Allergology, Faculty of Medicine and University Hospital Cologne, University Children's Hospital Cologne, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0009-0007-8935-6693
Jana SchönenkorbPediatric Pulmonology and Allergology, Faculty of Medicine and University Hospital Cologne, University Children's Hospital Cologne, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0009-0008-7425-7171
Robert BrockPediatric Pulmonology and Allergology, Faculty of Medicine and University Hospital Cologne, University Children's Hospital Cologne, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0001-7882-127X
Sarah ThullFaculty of Medicine and University Hospital Cologne, Institute of Human Genetics, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0003-3025-6106
Christian NetzerFaculty of Medicine and University Hospital Cologne, Institute of Human Genetics, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0002-9416-0712
Clara VelmansFaculty of Medicine and University Hospital Cologne, Institute of Human Genetics, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0002-3352-1035
Norah AltuwaijriGenomic Medicine Center of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-7385-8970
Issam R HamadahDepartment of Dermatology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.ORCID https://orcid.org/0009-0009-5848-1744
Ruqaiah AltassanMedical Genomic Department, Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0003-0146-8169
Ahmed AlfaresGenomic Medicine Center of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0003-4222-0952
Sateesh MaddirevulaGenomic Medicine Center of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0003-2999-2229
Siddaramappa Jagdish PatilDivision of Medical Genetics, Narayana Hrudayalaya Hospital, Mazumdar-Shaw Medical Center, Bangalore, India.ORCID https://orcid.org/0000-0001-7154-3449
Diana K BayerDepartment of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.ORCID https://orcid.org/0000-0001-7181-7446
Jonathan J Lyons *Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-2346-8189
Stuart E Turvey *Department of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-1599-1065
Funding
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MTPSAB1-derived tryptases promote myeloproliferation and anaphylaxisR00AI138586 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jonathan Lyons · 2024 to 2026
$2.3MIdentifying Genes for Type 2 Diabetes: FUSIONR56DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L · 2008 to 2008
$500kNIAID NIH HHS R00 AI138586NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R56 DK062370NIDDK NIH HHS U01 DK062370
Abstract
Oncostatin M (OSM) receptor beta (OSMRβ), encoded by
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.