ArticleJournal of inflammation research2026
Association Between the Aggregate Index of Systemic Inflammation and Non-Dipper Blood Pressure Pattern in Hypertensive Patients with Type 2 Diabetes Mellitus.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to investigate the association between the Aggregate Index of Systemic Inflammation (AISI) and non-dipper blood pressure (BP) pattern in hypertensive (HT) patients with type 2 diabetes mellitus (DM). Given the well-established role of systemic inflammation in circadian BP regulation, we hypothesized that elevated AISI levels would be associated with impaired nocturnal BP decline. Patients and Methods: A total of 356 newly diagnosed HT patients with type 2 DM and 170 normotensive control subjects were included in this observational study. HT patients were further classified as dipper (n=186) or non-dipper (n=170) based on 24-hour ambulatory blood pressure monitoring (ABPM). AISI was calculated using neutrophil, lymphocyte, platelet, and monocyte counts. Correlation analyses were performed to evaluate the relationship between AISI and ambulatory BP parameters. Multivariate logistic regression analysis with a backward stepwise method was conducted to determine independent predictors of non-dipper status. Receiver operating characteristic (ROC) curve analysis was used to assess the discriminative performance of AISI and other inflammatory indices. Results: AISI and ln(AISI) levels were significantly higher in non-dipper HT patients than in dipper HT patients and normotensive controls (p<0.001 for all). Ln(AISI) was positively correlated with nighttime systolic and diastolic BP (p<0.05). In multivariate logistic regression analysis, ln(AISI) emerged as the strongest independent predictor of non-dipper blood pressure pattern (OR: 14.13, 95% CI: 3.68-54.32, p<0.001). In ROC analysis, ln(AISI) showed the highest discriminative performance for identifying non-dipper status, with a sensitivity of 71.0% and specificity of 74.1% at a cutoff value of 5.80 (AUC: 0.757, p<0.001), outperforming NLR, PLR, SII, and SIRI. Conclusion: Elevated AISI levels were independently associated with non-dipper blood pressure pattern in hypertensive patients with type 2 diabetes mellitus. These findings suggest that AISI may serve as a practical and integrative biomarker for identifying high-risk patients with impaired circadian blood pressure regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.