ArticleBreast cancer (Dove Medical Press)2026
Characterization and Cytotoxicity of West Java Coffee Extracts, Chlorogenic Acid, Caffeine on MDA-MB-231, MCF-7 Cell Lines, and Their Impact on
Article in Breast cancer (Dove Medical Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Coffee bean extracts have been widely investigated for their potential anticancer properties, particularly due to bioactive compounds such as chlorogenic acid and caffeine. Breast cancer development involves complex genetic and signaling alterations, including dysregulation of the Wnt/β-catenin pathway. Purpose: To determine the phytochemical composition and quantify caffeine and chlorogenic acid in West Java coffee bean extracts. The study assessed their effects on the viability of MDA-MB-231 and MCF-7 breast cancer cells, and examined impacts on the Wnt pathway, focusing on Methods: Phytochemical screening and HPLC analysis are used to measure chlorogenic acid and caffeine in green and roasted coffee extracts. Cytotoxic activity and IC Results: Roasting and extraction methods affected phytochemicals, with higher temperatures reducing chlorogenic acid levels. Coffee extracts showed cytotoxicity against MDA-MB-231 (IC Conclusion: Coffee bean extracts, especially chlorogenic acid-rich green coffee, show selective antiproliferative effects in breast cancer cells and may act through Wnt signaling rather than estrogen receptors. More in vivo and mechanistic studies are needed to confirm their potential as complementary or preventive anticancer agents.
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