ArticleFrontiers in medicine2026
Associations of systemic immune-inflammation index and aggregate index of systemic inflammation with acute gouty arthritis in men: a cross-sectional study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exploratory evaluation of the systemic inflammatory response index and internally evaluated machine learning models for prognosis in acute pesticide poisoning.American journal of translational research · 2026Article
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4 authors.
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Abstract
Objective: This study aims to evaluate the associations of complete blood cell count-derived inflammatory markers-including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), Systemic Immune-Inflammation Index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI)-with acute gouty arthritis in males. Methods: A cross-sectional study was conducted in 380 males from the Department of Endocrinology and Department of Physical Examination, Central Hospital of Dalian University of Technology, between January 2022 and January 2024. Multivariable logistic regression models were used to investigate the independent associations between six inflammatory markers and acute gouty arthritis. Restricted cubic splines (RCS) were employed to model the dose-response relationships of inflammatory markers with acute gouty arthritis. Subgroup analyses were performed to identify susceptible populations. The diagnostic capabilities of the inflammatory markers were evaluated and compared using receiver operating characteristic (ROC) curves. Results: A total of 380 male participants were included, with a mean age of 54 years. Among them, 108 participants had AGA, giving a prevalence of 28.4%. Significant associations with AGA were observed for monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), Systemic Immune-Inflammation Index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI). Further analysis using RCS revealed nonlinear dose-response relationships between SII and AGA ( Conclusion: In men, AGA is closely associated with inflammatory markers. In addition, compared with other inflammatory markers (MLR, NLR, PLR, and SIRI), SII and AISI may serve as more accurate indicators for the diagnosis of AGA.
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