Evidence map›Paper›PMID 42221123›Full record

ArticleFrontiers in medicine2026

Genetic analysis of

Huizi Sun, Libin Mei, Xuemei He, Haijie Gao, Xianjing Huang, Jiayan Chen, Meijiao Cai, Ping Li, Yunsheng Ge, Yanru Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huizi Sun *Department of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Libin Mei *Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Xuemei HeDepartment of Reproductive Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Haijie GaoDepartment of Reproductive Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Xianjing HuangDepartment of Reproductive Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Jiayan ChenDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Meijiao CaiDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Ping LiDepartment of Reproductive Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Yunsheng GeDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Yanru HuangDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Hemophilia A (HA) is an X-linked recessive bleeding disorder caused by mutations in the Methods: Genomic DNA was extracted from peripheral blood samples. High-throughput sequencing was used to screen for mutations in 455 genes associated with genetic diseases. Long-range PCR (LR-PCR) was employed to detect the inversion of introns 1 and 22 of the Results: Subject 1 carried an intron 22 inversion (Inv22) of the Conclusion: All five subjects carried pathogenic

Indexed as

carrier screeningcopy-number variationF8 genegene varianthemophilia A

Identifiers

PMID42221123
PMCPMC13218909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.