Evidence map›Paper›PMID 42221118›Full record

ArticleFrontiers in medicine2026

Systemic inflammation and extra-articular manifestations in rheumatoid arthritis: a cross-sectional study.

Karlygash Sadykova, Gulnaz Nuskabayeva, Ainash Oshibayeva, Shakhnoza Tatykayeva, Elmira Iskandirova, Arzu Mamutova, Aziza Djurabekova, Ugilzhan Tatykayeva

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karlygash SadykovaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.
Gulnaz NuskabayevaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.
Ainash OshibayevaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.
Shakhnoza TatykayevaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.
Elmira IskandirovaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.
Arzu MamutovaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.
Aziza DjurabekovaSamarkand State Medical University, Samarkand, Uzbekistan.
Ugilzhan TatykayevaKhoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rheumatoid arthritis (RA) is a bodywide inflammatory condition that produces additional symptoms outside the joints that make the disease more severe and lead to patient disability and death. This research investigated various factors associated with the presence of extra-articular manifestations in RA patients. Methods: The cross-sectional study was conducted from 2023 to 2025 and assessed 299 adult patients who received RA confirmation. Clinical assessments, laboratory tests, and instrumental results were evaluated for extra-articular manifestations, and univariable and multivariable logistic regression analyses were performed to examine these relationships. Results: Extra-articular manifestations were present in 278 patients (93%). Patients with extra-articular manifestations were older (

Indexed as

erythrocyte sedimentation rateextra-articular manifestationsinflammatory markersreal-world studyrheumatoid arthritissystemic inflammation

Identifiers

PMID42221118
PMCPMC13218873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.